CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
Skowera, Ania, Ellis, Richard J, Varela-Calviño, Ruben, Arif, Sefina, Huang, Guo Cai, Van-Krinks, Cassie, Zaremba, Anna, Rackham, Chloe, Allen, Jennifer S, Tree, Timothy I M, Zhao, Min, Dayan, Colin M, Sewell, Andrew K, Unger, Wendy W, Unger, Wendy, Drijfhout, Jan W, Ossendorp, Ferry, Roep, Bart O, Peakman, Mark
The Journal of clinical investigation 2008 Oct;118: 3390-402