Catalogue Number
CT257
Description
mAb anti-human IL-12/IL-23 p40 (B-P24) - 0.5 mg
Price
€ 300.00
Characteristics
clone B-P24
Summary
The monoclonal antibody binds both natural and recombinant human IL-12 (p35/p40) and IL-23 (p19/p40) heterodimers via the p40 subunit in vitro. Blocks IL-12 induced proliferation of PHA and IL-2 activated lymphocytes.
References list
- Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation.
- Gram-positive bacteria are potent inducers of monocytic interleukin-12 (IL-12) while gram-negative bacteria preferentially stimulate IL-10 production.
- Down-regulation of IL-12 by topical corticosteroids in chronic atopic dermatitis.