The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys.

Year	Reference
2007	The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys. Brok, Herbert P M Boven, Leonie van Meurs, Marjan Kerlero de Rosbo, Nicole Celebi-Paul, Liesbeth Kap, Yolanda S Jagessar, Anwar Hintzen, Rogier Q Keir, Geoff Bajramovic, Jeffrey Ben-Nun, Avraham Bauer, Jan Laman, Jon D Amor, Sandra 't Hart, Bert A Journal of neuroimmunology 2007 Jan;182: 135-52

Year

Reference

2007

The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys.

Brok, Herbert P M

Boven, Leonie

van Meurs, Marjan

Kerlero de Rosbo, Nicole

Celebi-Paul, Liesbeth

Kap, Yolanda S

Jagessar, Anwar

Hintzen, Rogier Q

Keir, Geoff

Bajramovic, Jeffrey

Ben-Nun, Avraham

Bauer, Jan

Laman, Jon D

Amor, Sandra

't Hart, Bert A

Journal of neuroimmunology 2007 Jan;182: 135-52

Abstract

Rhesus monkeys immunized with MOG(34-56), a dominant T-cell epitope from myelin/oligodendrocyte glycoprotein, develop an acute neurological disease resembling acute disseminated encephalomyelitis (ADEM) in humans. The typical large demyelinated lesions and mononuclear infiltrates in the monkey brains are caused by MOG(34-56) T-cells. We show that MOG(34-56)-reactive CD4+ and CD8+ T-cells are induced in monkeys immunized with a peptide from the human CMV major capsid protein (UL86; 981-1003), that shares sequence similarity with MOG(34-56). Monkeys sensitized against the viral peptide and subsequently challenged with MOG(34-56) display histological signs of encephalitis, but do not show overt neurological signs.

Original publication

https://www.ncbi.nlm.nih.gov/pubmed/17126916?dopt=Abstract

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