Anti-granuloma activity of Coriandrum sativum in experimental models.
Journal of Ayurveda and integrative medicine 2013 Jan;4: 13-8
BACKGROUND: Coriandrum sativum has been used in the traditional systems of medicine for management of arthritis and other inflammatory disorders.
OBJECTIVES: In this study, we have evaluated the anti-inflammatory and anti-granuloma activities of Coriandrum sativum hydroalcoholic extract (CSHE) in experimental models.
MATERIALS AND METHODS: The anti-inflammatory activity of CSHE was evaluated using carrageenan-induced paw edema model and the anti-granuloma activity of CSHE was evaluated using the subcutaneous cotton pellet implantation-induced granuloma formation and stimulation of peritoneal macrophages with complete Freund's adjuvant. Serum tumor necrosis factor-α (TNF-α), IL-6, IL-1 β levels, and peritoneal macrophage expression of TNF-R1 were evaluated as markers of global inflammation.
RESULTS: CSHE at the highest dose tested (32 mg/kg) produced a significant reduction (P
CONCLUSION: Thus, the result of this study demonstrates the anti-inflammatory and anti-granuloma activities of CSHE in experimental models, and validates its traditional use for the management of arthritis and other inflammatory disorders.