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Interferon-beta modulates protein synthesis in the central nervous system.
Beyer, Susanne
Raether, Gergana
Stadler, Konstantin
Hoffrogge, Raimund
Scharf, Christian
Rolfs, Arndt
Mix, Eilhard
Strauss, Ulf
Journal of neuroimmunology 2009 Aug 18;213: 31-8

Interferon-beta (IFN-beta), acting canonically via the modulation of transcription, affects neocortical pyramidal neurons. By use of 2-D differential gel electrophoresis and subsequent mass spectrometry we identified IFN-beta regulated proteins in the central nervous system. These proteins are involved in cytoskeleton assembly, protein transport and nucleotide metabolism and, as such, serve regenerative and protective functions. Electrophysiologically, IFN-beta mediated protein synthesis is essential for part of the excitatory neuronal effects, as revealed under blockade of protein biosynthesis. This study presents novel effects of IFN-beta in the central nervous system and begins to unravel the mechanism behind the known excitability changes in neurons.

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